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Prof. em. Dr. Martin E. Schwab
Academic Senior Guest at the Institute for Regenerative Medicine
Neural Regeneration and Repair
M. Schwab’s expertise is in developmental neurobiology and mechanisms of repair of the brain and spinal cord. He postulated the concept of “inhibitors of neurite growth” as a cause of the absent regeneration of injured fiber tracts in the central nervous system and isolated one of the most potent nerve fiber growth inhibitors, the membrane protein Nogo-A. When this component was blocked by specific anti-Nogo-A antibodies generated in the lab, regeneration and functional repair could be shown for the first time in adult rats and monkeys after spinal cord injury. Cell biological studies revealed the mechanism of action of Nogo-A, its receptors and its functional role in the developing and adult CNS. Clinical trials testing the effects of anti-Nogo-A antibodies in spinal cord injured patients are currently on-going.
Martin E. Schwab was a Senior Professor and research group leader at the Institute for Regenerative Medicine and em. Professor at the Department of Health Sciences and Technology of ETH Zurich. He currently acts as CSO and President of the UZH spin-off company Novago Therapeutics Inc.
He is currently as an Academic Advisory Senior Professor at the Institute for Regenerative Medicine.
Current Address:
Prof. Dr. Martin E. Schwab
NovaGo Therapeutics, Wagistrasse 27, 8952 Schlieren
e-mail: martin@novagotx.com
