Publication List

2018

Haenseler W, Kuzmenko E, Smalls-Mantey A, Browne C, Seger R, James WS, Cowley SA*, Reichenbach J*, Siler U*. Lentiviral gene therapy vector with UCOE stably restores function in iPSC-derived neutrophils of a CDG patient. ScienceMatters 2018; May 23rd, 2018 * Equal contribution

Cytlak U, Resteu A, Bogaert D,Kuehn HS, Altmann T, Gennery A, Jackson G, Kumanovics A, Voelkerding K, Prader S, Dullaers M, Reichenbach J, Hill H, Haerynck F, Rosenzweig SD, Collin M, Bigley V. Ikaros family zinc finger 1 regulates dendritic cell development and function in humans. Nature Communications 2018; March 27

Maccari ME, Abolhassani H, Aghamohammadi A, Aiuti A, Aleinikova O, Bangs C, Baris S, Barzaghi F, Baxendale H, Buckland M, Burns SO, Cancrini C, Cant A, Cathébras P, Cavazzana M, Chandra A, Conti F, Coulter T, Devlin LA, Edgar JDM, Faust S, Fischer A, Garcia Prat M, Hammarström L, Heeg M, Jolles S, Karakoc-Aydiner E, Kindle G, Kiykim A, Kumararatne D, Grimbacher B, Longhurst H, Mahlaoui N, Milota T, Moreira F, Moshous D, Mukhina A, Neth O, Neven B, Nieters A, Olbrich P, Ozen A, Pachlopnik Schmid J, Picard C, Prader S, Rae W, Reichenbach J, Rusch S, Savic S, Scarselli A, Scheible R, Sediva A, Sharapova SO, Shcherbina A, Slatter M, Soler-Palacin P, Stanislas A, Suarez F, Tucci F, Uhlmann A, van Montfrans J, Warnatz K, Williams AP, Wood P, Kracker S, Condliffe AM, Ehl S. Disease evolution and response to rapamycin in Activated PI3Kδ Syndrome: the ESID-APDS registry. Frontiers in Immunology 2018; March 16

Lewandowska DW, Capaul R, Prader S, Zagordi O, Geissberger FD, Kugler M, Knorr M, Berger C, Gungor T, Reichenbach J, Shah C, Boni J, Zbinden A, Trkola A, Schmid J, Huber M. Persistent mammalian orthoreovirus, coxsackievirus and adenovirus co-infection in a child with a primary immunodeficiency detected by metagenomic sequencing: a case report. BMC Infectious Dis 2018;Jan 11

2017

Wrona D, Siler U, Reichenbach J. CrispR/Cas9-generated p47phox-deficient cell line for Chronic Granulomatous Disease gene therapy vector development. Scientific Reports (Nature Publishing Group) 2017;7:44187

Vaas M, Enzmann G, Perinat T, Siler U, Reichenbach J, Licha K, Kipar A, Rudin M, Engelhardt B, Klohs J. Non-invasive near-infrared fluorescence imaging of the neutrophil response in a mouse model of transient cerebral ischaemia. J Cereb Blood Flow Metab, 2017;37(8):2833-2847

Siler U, Romao S, Tejera E, Pastukhov O, Kuzmenko E, Valencia RG, Spaccamela VM, Belohradsky BH, Speer O, Schmugge M, Kohne E, Hoenig M, Freihorst J, Schulz AS, Reichenbach J. Severe glucose-6-phosphate dehydrogenase deficiency leads to susceptibility to infection and absent NETosis. J Allergy Clin Immunol, 2017;139(1):212-219.e3

2016

Marquardt L, Lacour M, Hoernes M, Opitz L, Lecca R, Volkmer B, Reichenbach J, Hohl D, Ansari M, Ozsahin H, Güngör T, Pachlopnik Schmid J. Unusual dermatological presentation and immune phenotype in SCID due to an IL7R mutation: the value of whole-exome sequencing and the potential benefit of newborn screening. J Eur Acad Dermatol Venereol, 2016 Sep 5.

Elkaim E, Neven B, Bruneau J, Mitsui-Sekinaka K, Stanislas A, Heurtier L, Lucas CL, Matthews H, Deau MC, Sharapova S, Curtis J, Reichenbach J, Glastre C, Parry DA, Arumugakani G, McDermott E, Kilic SS, Yamashita M, Moshous D, Lamrini H, Otremba B, Gennery A, Coulter T, Quinti I, Stephan JL, Lougaris V, Brodszki N, Barlogis V, Asano T, Galicier L, Boutboul D, Nonoyama S, Cant A, Imai K, Picard C, Nejentsev S, Molina TJ, Lenardo M, Savic S, Cavazzana M, Fischer A, Durandy A, Kracker S. Clinical and immunologic phenotype associated with activated phosphoinositide 3-kinase δ syndrome 2: A cohort study. J Allergy Clin Immunol, 2016 Jul;138(1):210-218.e9

Toubiana J, Okada S, Hiller J, Oleastro M, Lagos Gomez M, Aldave Becerra JC, Ouachée-Chardin M, Fouyssac F, Girisha KM, Etzioni A, Van Montfrans J, Camcioglu Y, Kerns LA, Belohradsky B, Blanche S, Bousfiha A, Rodriguez-Gallego C, Meyts I, Kisand K, Reichenbach J, Renner ED, Rosenzweig S, Grimbacher B, van de Veerdonk FL, Traidl-Hoffmann C, Picard C, Marodi L, Morio T, Kobayashi M, Lilic D, Milner JD, Holland S, Casanova JL, Puel A; International STAT1 Gain-of-Function Study Group. Heterozygous STAT1 gain-of-function mutations underlie a broad clinical phenotype: an international survey of 234 patients from 140 kindreds. STAT1 gain of function mutations underlie an unexpectedly broad clinical phenotype: an international survey of 274 patients. Blood, 2016 Jun 23;127(25):3154-64.

Kuehn HS*, Boisson B*, Cunningham-Rundles C, Reichenbach J, Stray-Pedersen A, Gelfand EW, Maffucci P, Pierce KR, Abbott JK, Voelkerding KV, South ST, Augustine NH, Bush JS, Dolen WK, Wray BB, Itan Y, Cobat A, Sorte HS, Ganesan S, Prader S, Martins TB, Lawrence MG, Orange JS, Calvo KR, Niemela JE, Casanova JL, Fleisher TA, Hill HR, Kumánovics A, Conley ME*, Rosenzweig SD*. Loss of B Cells in Patients with Heterozygous Mutations in IKAROS. N Engl J Med 2016 Mar 17;374(11):1032-43. * Equal contribution

Weisser M, Demel UM, Stein S, Chen-Wichmann L, Touzot F, Santilli G, Sujer S, Brendel C, Siler U, Cavazzana M, Thrasher AJ, Reichenbach J, Essers MA, Schwäble J, Grez M. Hyperinflammation in Chronic Granulomatous Disease leads to impairment of hematopoietic stem cell functions. J Allergy Clin Immunol 2016, 138(1):219-228.e9.

2015

Romao S, Tejera Puente E, Nytko KJ, Siler U, Münz C, Reichenbach J. Defective nuclear entry of hydrolases prevents NETosis in Chronic Granulomatous Disease. J Allergy Clin Immunol 2015; 136(6):1703-1706.e5

Harbort CJ, Soeiro-Pereira PV, von Bernuth H, Kaindl AM, Costa-Carvalho BT, Condino-Neto A, Reichenbach J, Roesler J, Zychlinsky A, Amulic B. Neutrophil oxidative burst activates ATM to regulate cytokine production and apoptosis. Blood 2015; 126(26):2842-51

Dreyer AK, Hoffmann D, Lachmann N, Ackermann M, Steinemann D, Timm B, Siler U, Reichenbach J, Grez M, Moritz T, Schambach A, Cathomen T. TALEN-mediated functional correction of X-linked chronic Granulomatous disease in patient-derived induced pluripotent stem cells. Biomaterials 2015; 69:191-200.

Marschall K, Hoernes M, Bitzenhofer-Grüber M, Jandus P, Duppenthaler A, Wuillemin WA, Rischewski J, Boyman O, Heininger U, Hauser T, Steiner U, Posfay-Barbe K, Seebach J, Recher M, Hess C, Helbling A, Reichenbach J. The Swiss National Registry for Primary Immunodeficiencies: Report on the first 6 years’ activity 2008-2014. Clin Exp Immunol 2015;182: 45–50.

Siler U*, Paruzynski A*, Holtgreve-Grez H, Kuzmenko E, Koehl U, Renner ED, Alhan C, van de Loosdrecht AA, Schwäble J, Pfluger T, Tchinda J, Schmugge M, Jauch A, Naundorf S, Kühlcke K, Notheis G, Güngör T, v. Kalle C, Schmidt M* Equal contribution, Grez M*, Seger R*, Reichenbach J*. Sequential gene therapy and successful rescue HSCT in two children with X-CGD – importance of timing. Curr Gene Ther 2015;15(4):416-27 * Equal contribution

Bielas H, Jud A, Lips U, Reichenbach J, Wieser I, Landolt MA. Preliminary Evidence for a Compromised T-Cell Compartment in Maltreated Children with Depression and Posttraumatic Stress Disorder. Neuroimmunomodulation 2015;22(5):303-10

2014

1.

Fiaschetti G, Abela L, Nonoguchi N, Dubuc AM, Remke M, Boro A, Grunder E, Siler U, Ohgaki H, Taylor MD, Baumgartner M, Shalaby T, Grotzer MA. Epigenetic silencing of miRNA-9 is associated with HES1 oncogenic activity and poor prognosis of medulloblastoma. Br J Cancer. 2014; 110: 636-47

2013

Romao S, Gasser N, Becker AC, Guhl B, Bajagic M, Vanoaica D, Ziegler U, Roesler J, Dengjel J, Reichenbach J, Munz C. Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing. J Cell Biol 2013;203(5):757-66.

Brendel C, Hanseler W, Wohlgensinger V, Bianchi M, Tokmak S, Chen-Wichmann L, Kouzmenco E, Cesarovic N, Nicholls F, Reichenbach J, Seger R, Grez M, Siler U. Human miR223 Promoter as Novel Myelospecific Promoter for CGD Gene Therapy. Human Gene Ther 2013; 24(3):151-9.

2012

Bielas H, Jud A, Lips U, Reichenbach J, Landolt MA. Increased number of activated T cells in lymphocyte subsets of maltreated children: Data from a pilot study. J Psychosom Res 2012;73(4):313-8.

Patel K, Akhter J, Kobrynski L, Gathman B, Davis O, Sullivan KE; International DiGeorge Syndrome Immunodeficiency Consortium (Reichenbach J as ESID Member). Immunoglobulin deficiencies: the B-lymphocyte side of DiGeorge Syndrome. J Pediatr 2012;161(5):950-3.

Cliffe ST, Bloch DB, Suryani S, Kamsteeg EJ, Avery DT, Palendira U, Church J, Wainstein B, Trizzino A, Lefranc G, Akatcherian C, Megarbané A, Gilissen C, Moshous D, Reichenbach J, Misbah S, Salzer U, Abinun M, Ong P, Stepensky P, Ruga E, Ziegler JB, Wong M, Tangye SG, Lindeman R, Buckley MF and Roscioli T. Clinical, Molecular and Cellular Immunology Findings in SP110-associated Veno-occlusive Disease with Immunodeficiency Syndrome. J Allergy Clin Immunol 2012;130(3):735-742.e6.

Jiang Y, Cowley SA, Siler U, Melguzo D, Tilgner K, Browne K, deWilton A, Pryzborski S, Saretzki G, Seger RA, James WS, Reichenbach J, Lako M, Armstrong L. Derivation and functional analysis of patient specific induced pluripotent stem cells as an in vitro model of Chronic Granulomatous Disease. Stem Cells 2012; 30:599-611.

Meyer-Bahlburg A, Renner ED, Rylaarsdam S, Reichenbach J, Schimke LF, Marks A, Tcheurekdjian H, Hostoffer R, Brahmandam A, Torgerson TR, Belohradsky BH, Rawlings DJ, Ochs HD. Heterozygous STAT3 mutations in hyper-IgE syndrome result in altered B cell maturation. J Allergy Clin Immunol 2012; 129(2), 559–562.e2

2011

Liu L, Okada S, Kong XF, Kreins AY, Cypowyj S, Abhyankar A, Toubiana J, Itan Y, Audry M, Nitschke P, Masson C, Toth B, Flatot J, Migaud M, Chrabieh M, Kochetkov T, Bolze A, Borghesi A, Toulon A, Hiller J, Eyerichs S, Eyerichs K, Gulácsy V, Chernyshova L, Chernyshov V, Bondarenko A, Cortés Grimaldo RM, Blancas Galicia L, Madrigal Beas IM, Roesler J, Magdorf K, Engelhardt D, Thumerelle C, Burgel PR, Hoernes M, Drexel B, Seger R, Kusuma T, Jansson AF, Sawalle-Belohradsky J, Belohradsky B, Jouanguy E, Bustamante J, Bué M, Bodemer C, Lortholary O, Fischer A, Blanche S, Al-Muhsen S, Reichenbach J, Kobayashi M, Torres Lozano C, Sebnem Kilic S, Oleastro M, Etzioni A, Traidl-Hoffmann C, Renner ED, Abel L, Picard C, Maródi L, Boisson-Dupuis S, Puel A and Casanova JL. Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. J Exp Med 2011;208(8):1635-48.

Nakagawa N, Imai K, Kanegane H, Sato H, Yamada M, Kondo K, Okada S, Kobayashi M, Takada H, Mitsuiki N, Oshima K, Ohara O, Suri D, Rawat A, Singh S, Pan-Hammarström Q, Hammarström L, Reichenbach J, Seger R, Ariga T, Hara T, Miyawaki T, Nonoyama S. Newborn screening of B cell deficiencies by measuring kappa-deleting recombination excision circles in Guthrie cards. J Allergy Clin Immunol 2011; 128(1):223-225.e2.

Audry M, Ciancanelli M, Yang K, Cobat A, Chang HH, Sancho-Shimizu V, Lorenzo L, Niehues T, Reichenbach J, Li XX, Israel A, Abel L, Casanova JL, Zhang SY, Jouanguy E, Puel A. NEMO is a key component of NF-B- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus. J Allergy Clin Immunol 2011;128(3):610-7.e1-4.

Bianchi M, Niemiec MJ, Siler U, Urban CF*, Reichenbach J*. Restoration of anti-Aspergillus defense by NETs in human CGD is Calprotectin-dependent. J Allergy Clin Immunol 2011;127(5):1243-1252. * Equal contribution

2010

de Beaucoudrey L, Samarina A, Bustamante J, Cobat A, Boisson-Dupuis S, Feinberg J, Al-Muhsen S, Jannière L, Rose Y, de Suremain M, Kong XF, Filipe-Santos O, Chapgier A, Picard C, Fischer A, Dogu F, Ikinciogullari A, Tanir G, Al-Hajjar S, Al-Jumaah S, Frayha HH, Alsum Z, Al-Ajaji S, Alangari A, Al-Ghonaium A, Adimi P, Mansouri D, Ben-Mustapha I, Yancoski J, Garty BZ, Rodriguez-Gallego C, Caragol I, Kutukculer N, Kumararatne DS, Patel S, Doffinger R, Exley A, Jeppsson O, Reichenbach J, Nadal D, Boyko Y, Pietrucha B, Anderson S, Levin M, Schandené L, Schepers K, Efira A, Mascart F, Matsuoka M, Sakai T, Siegrist CA, Frecerova K, Blüetters-Sawatzki R, Bernhöft J, Freihorst J, Baumann U, Richter D, Haerynck F, De Baets F, Novelli V, Lammas D, Vermylen C, Tuerlinckx D, Nieuwhof C, Pac M, HaasWH, Müller-Fleckenstein I, Fleckenstein B, Levy J, Raj R, Cohen AC, Lewis DB, Holland SM, Yang KD, Wang X, Wang X, Jiang L, Yang X, Zhu C, Xie Y, Lee PP, Chan KW, Chen TX, Castro G, Natera I, Codoceo A, King A, Bezrodnik L, Di Giovani D, Gaillard MI, de Moraes-Vasconcelos D, Grumach AS, da Silva Duarte AJ, Aldana R, Espinosa-Rosales FJ, Bejaoui M, Bousfiha AA, Baghdadi JE, Ozbek N, Aksu G, Keser M, Somer A, Hatipoglu N, Aydogmus C, Asilsoy S, Camcioglu Y, Gülle S, Ozgur TT, Ozen M, Oleastro M, Bernasconi A, Mamishi S, Parvaneh N, Rosenzweig S, Barbouche R, Pedraza S, Lau YL, Ehlayel MS, Fieschi C, Abel L, Sanal O, Casanova JL. Revisiting Human IL-12Rβ1 Deficiency: A Survey of 141 Patients From 30 Countries. Medicine (Baltimore). 2010;89:381-402.

He B, Santamaria R, Xu W, Cols M, Chen K, Puga I, Shan M, Xiong H, Bussel JB, Chiu A, Puel A, Reichenbach J, Marodi L, Döffinger R, Vasconcelos J, Issekutz A, Krause J, Davies G, Li X, Grimbacher B, Plebani A, Meffre E, Picard C, Cunningham-Rundles C, Casanova JL, Cerutti A. The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. Nat Immunol 2010;11:836-45.

Jürgens B, Fuchs D, Reichenbach J^*, Heitger A^*. Intact indoleamine 2,3 dioxygenase activity in human chronic granulomatous disease. Clin Immunol 2010;137:1-4. * Equal contribution

Kieslich M, Hoche F, Reichenbach J, Weidauer S, Porto L, Vlaho S, Schubert R, Zielen S. Extracerebellar MRI-Lesions in Ataxia Telangiectasia Go Along with Deficiency of the GH/IGF-1 Axis, Markedly Reduced Body Weight, High Ataxia Scores and Advanced Age. Cerebellum 2010;9:190-7.

Meissner F, Seger RA, Moshous D, Fischer A, Reichenbach J*, Zychlinsky A*. Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease. Blood 2010;116:1570-3. * Equal contribution

Editorial on article: Latz E. NOX-free inflammasome activation. Blood 2010;116: 1393-1394.

Picard C, von Bernuth H, Ghandil P, Chrabieh M, Levy O, Arkwright PD, McDonald D, Geha RS, Takada H, Krause JC, Creech CB, Ku CL, Ehl S, Maródi L, Al-Muhsen S, Al-Hajjar S, Al-Ghonaium A, Day-Good NK, Holland SM, Gallin JI, Chapel H, Speert DP, Rodriguez-Gallego C, Colino E, Garty BZ, Roifman C, Hara T, Yoshikawa H, Nonoyama S, Domachowske J, Issekutz AC, Tang M, Smart J, Zitnik SE, Hoarau C, Kumararatne DS, Thrasher AJ, Davies EG, Bethune C, Sirvent N, de Ricaud D, Camcioglu Y, Vasconcelos J, Guedes M, Vitor AB, Rodrigo C, Almazán F, Méndez M, Aróstegui JI, Alsina L, Fortuny C, Reichenbach J, Verbsky JW, Bossuyt X, Doffinger R, Abel L, Puel A, Casanova JL. Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency. Medicine (Baltimore). 2010;89:403-425.

Schimke LF, Sawalle J, Roesler J, Wollenberg A, Rack A, Borte M, Rieber N, Cremer R, Maaß E, Dopfer R, Reichenbach J, Wahn V, Hoenig M, Jansson AF, Roesen-Wolff A, Schaub B, Seger R, Hill HR, Ochs HD, Torgerson TR, Belohradsky BH, Renner ED. Diagnostic approach to the hyper-IgE syndromes (HIES): Immunological and clinical key findings to differentiate HIES from atopic dermatitis. J Allergy Clin Immunol 2010;126:611-617.e1.

Schubert R, Reichenbach J, Koch C, Kloess S, Koehl U, Mueller K, Baer P, Beermann C, Boehles H, Zielen S. Reactive oxygen species abrogate the anticarcinogenic effect of eicosapentaenoic acid in Atm-deficient mice. Nutr Cancer 2010;62:584-92.

Wohlgensinger V, Seger R, Ryan MD, Reichenbach J, Siler U. Signed outside: a surface marker system for transgenic cytoplasmic proteins. Gene Ther 2010;17:1193-9.

2009

Bianchi M, Hakkim Rahamathullah A, Brinkmann V, Siler U, Seger RA, Zychlinsky A*, Reichenbach J*. Restoration of NET formation by gene therapy in CGD controls aspergillosis. Blood 2009;114:2619-22. * Equal contribution

Morinishi Y, Imai K, Nakagawa N, Sato H, Horiuchi K, Ohtsuka Y, Kaneda Y, Taga T, Hisakawa H, Miyaji R, Endo M, Oh-Ishi T, Kamachi Y, Akahane K, Kobayashi C, Tsuchida M, Morio T, Sasahara Y, Kumaki S, Ishigaki K, Yoshida M, Urabe T, Kobayashi N, Okimoto Y, Reichenbach J, Hashii Y, Tsuji Y, Kogawa K, Yamaguchi S, Kanegane H, Miyawaki T, Yamada M, Ariga T, Nonoyama S. Identification of Severe Combined Immunodeficiency by T-Cell Receptor Excision Circles Quantification Using Neonatal Guthrie Cards. J Pediatr 2009;155:829-33.

Reichenbach J, Lopatin U, Mahlaoui N, Beovic B, Siler U, Zbinden R, Seger RA, Galmiche L, Brousse N, Kayal S, Güngör T, Blanche S, Holland SM. Actinomyces in Chronic Granulomatous Disease: An Emerging and Unanticipated Pathogen. Clin Infect Dis 2009;49:1703-10.

2008

de Beaucoudrey L, Puel A, Filipe-Santos O, Cobat A, Ghandil P, Chrabieh M, Feinberg J, von Bernuth H, Samarina A, Jannière L, Fieschi C, Stéphan JL, Boileau C, Lyonnet S, Jondeau G, Cormier-Daire V, Le Merrer M, Hoarau C, Lebranchu Y, Lortholary O, Chandesris MO, Tron F, Gambineri E, Bianchi L, Rodriguez-Gallego C, Zitnik SE, Vasconcelos J, Guedes M, Vitor AB, Marodi L, Chapel H, Reid B, Roifman C, Nadal D, Reichenbach J, Caragol I, Garty BZ, Dogu F, Camcioglu Y, Gülle S, Sanal O, Fischer A, Abel L, Stockinger B, Picard C, Casanova JL. Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells. J Exp Med 2008;205:1543-50.

Reichenbach J, Van de Velde H, De Rycke M, Staessen C, Platteau P, Baetens P, Güngör T, Ozsahin H, Scherer F, Siler U, Seger RA, Liebaers I. First successful bone marrow transplantation for chronic granulomatous disease using preimplantation female sexing and HLA-matching. Pediatrics 2008;122:e778-82.

Renner ED, Rylaarsdam S, Aňover-Sombke S, Rack A, Reichenbach J, Carey JC, Zhu Q, Jansson A, Barboza J, Schimke LF, Leppert MF, Getz MM, Seger RA, Hill HR, Belohradsky BH, Torgerson TR, Ochs HD. Noval signal transducer and activator of transcription 3 (STAT3) mutations, reduced T_H17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome. J Allergy Clin Immunol 2008;122:181-7.

Yousefi S, Gold JA, Andina N, Lee JJ, Kelly AM, Kozlowski E, Schmid I, Straumann A, Reichenbach J, Gleich GJ, Simon HU. Catapult-like release of mitochondrial DNA by eosinophils contributes to anti-bacterial defense. Nature Medicine 2008;14:949-53.

Puel A*, Reichenbach J*, Bustamante J, Ku CL, Feinberg J, Döffinger R, Bonnet M, Filipe Santos O, de Beaucoudrey L, Durandy A, Horneff G, Novelli F, Wahn V, Smahi A, Israel A, Niehues T, Casanova JL. The NEMO mutation creating the most upstream premature stop codon is hypomorphic owing to a re-initiation of translation. Am J Hum Genet 2006;78:691-701. * Equal contribution

2007

1.

Junge S, Kloeckener-Gruissem B, Zufferey R, Keisker A, Salgo B, Fauchere JC, Shalaby T, Grotzer M, Siler U, Seger R, Güngör T. Correlation between recent thymic emigrants and CD3(+) (PECAM-1) CD4(+) T cells in normal individuals during aging and in lymphopenic children. Eur J Immunol. 2007, 37: 3270-80.

2006

Reichenbach J, Schubert R, Feinberg J, Rosewich M, Rose M, Zielen S. Impaired IFN- production in response to live bacteria and Toll-like receptor agonists in patients with Ataxia Telangiectasia. Clin Exp Immunol 2006;146:381-9.

Reichenbach J, Schubert R, Horvath R, Fütterer N, Malle E, Stumpf A, Gebhardt B, Koehl U, Schraven B, S. Zielen. Fatal neonatal-onset mitochondrial respiratory chain disease with T cell immunodeficiency. Pediatr Res 2006;60:321-6.

Rose MA, Schubert R, Schmitt-Grohe S, Reichenbach J, Zielen S. Immunoglobulins and inflammatory cytokines in nasal secretions in humoral immunodeficiencies. Laryngoscope 2006;116:239-44.

Strnad-Trojan N, Linde R, Reichenbach J, Trojan J, Zeuzem S, Zielen S. Treatment of HCV and EBV co-infection with interferon alpha-2b and ribavirin in a patient with X-linked lymphoproliferative syndrome. Eur J Pediatr 2006;165:348-50.

Zielen S, Rose MA, Bez C, Jarisch A, Reichenbach J, Hofmann D. Effectiveness of budesonide nebulising suspension compared to disodium cromoglycate in early childhood asthma. Curr Med Res Opin 2006;22:367-73.

Ott MG*, Schmidt M*, Schwarzwaelder K*, Stein S*, Siler U*, Koehl U, Glimm H, Kuhlcke K, Schilz A, Kunkel H, Naundorf S, Brinkmann A, Deichmann A, Fischer M, Ball C, Pilz I, Dunbar C, Du Y, Jenkins NA, Copeland NG, Luthi U, Hassan M, Thrasher AJ, Hoelzer D, von Kalle C, Seger R, Grez M. Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med. 2006; 12: 401-9. * Equal contribution

2005

Schubert R, Reichenbach J, Zielen S. Growth factor deficiency in patients with ataxia telangiectasia. Clin Exp Immunol 2005;140:517-9.

Herzog A*, Siler U*, Spitzer V, Seifert N, Denelavas A, Buchwald Hunziker P, Hunziker W, Goralczyk R & Wertz K. Lycopene reduces gene expression of steroid targets and inflammatory markers in normal rat prostate. FASEB J. 2005; 19: 272-274. * Equal contribution

2004

Feinberg J, Fieschi C, Doffinger R, Feinberg M, Leclerc T, Boisson-Dupuis S, Picard C, Bustamante J, Chapgier A, Filipe-Santos O, Ku CL, de Beaucoudrey L, Reichenbach J, Antoni G, Balde R, Alcais A, Casanova JL. Bacillus Calmette Guerin triggers the IL-12/IFN-gamma axis by an IRAK-4- and NEMO-dependent, non-cognate interaction between monocytes, NK, and T lymphocytes. Eur J Immunol 2004;34:3276-84.

Niehues T*, Reichenbach J*, Neubert J, Gudowius S, Puel A, Horneff G, Lainka E, Dirksen U, Schroten H, Doffinger R, Casanova JL, Wahn V. Nuclear factor kappaB essential modulator-deficient child with immunodeficiency yet without anhidrotic ectodermal dysplasia. J Allergy Clin Immunol 2004;114:1456-62. * Equal contribution

Schubert R, Reichenbach J, Rose M, Zielen S. Immunogenicity of the seven valent pneumococcal conjugate vaccine in patients with ataxia telangiectasia. Pediatr Infect Dis J 2004;23: 269-70.

Siler U, Barella L, Spitzer V, Schnorr J, Lein M, Goralczyk R & Wert K. Lycopene and Vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model. FASEB J. 2004; 18: 1019-1021

2003

Courtois G, Smahi A*, Reichenbach J*, Doffinger R, Cancrini C, Bonnet M, Puel A, Chable-Bessia C, Yamaoka S, Feinberg J, Dupuis-Girod S, Bodemer C, Livadiotti S, Novelli F, Rossi P, Fischer A, Israël A, Munnich A, Le Deist F, Casanova JL. A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency. J Clin Invest 2003;112:1108-15. * Equal contribution

Bez C, Sach G, Jarisch A, Rosewich M, Reichenbach J, Zielen S. Safety and tolerability of methacholine challenge in infants with recurrent wheeze. J Asthma 2003;40(7):795-802.

2002

Reichenbach J, Jarisch A, Khan S, Hömberg M, Bez C, Zielen S. Serum ECP levels and methacholine challenge in infants with recurrent wheezing. Ann Allergy Asthma Immunol 2002;89:1-5.

Reichenbach J, Schubert R, Schindler D, Muller K, Bohles H, Zielen S. Elevated oxidative stress in patients with ataxia telangiectasia. Antioxid Redox Signal 2002;4:465-69.

Schubert R, Reichenbach J, Zielen S. Deficiencies in CD4+ and CD8+ T cell subsets in ataxia telangiectasia. Clin Exp Immunol 2002;129:125-32.

Siler U, Rousselle P, Müller C, Klein G. Laminin 2 chain as a stromal marker of the human bone marrow microenvironment. Br J Haematology 2002; 119: 212-220

Kutlesa S,* Siler U,* Speriser A, Wessel JT, Virtanen I, Rousselle P, Sorokin LM, Mueller CA, Klein G. Developmentally regulated interactions of human thymocytes with different laminin isoforms. Immunology 2002; 106: 1-17. * Equal contribution

2001

Altare F, Ensser A, Breiman A, Reichenbach J, Baghdadi JE, Fischer A, Emile JF, Gaillard JL, Meinl E, Casanova JL. Interleukin-12 receptor beta1 deficiency in a patient with abdominal tuberculosis. J Infect Dis 2001;184:231-36.

2000

Pichler MN, Reichenbach J, Schmidt H, Herrmann G, Zielen S. Severe adenovirus bronchiolitis in children. Acta Paediatr 2000;89:1387-9.

Reichenbach J, Schubert R, Schwan C, Muller K, Bohles HJ, Zielen S. Antioxidative capacity in patients with common variable immunodeficiency. Clin Exp Immunol 2000;20:221-6.

Schubert R, Reichenbach J, Royer N, Pichler M, Zielen S. Spontaneous and oxidative stress-induced programmed cell death in lymphocytes from patients with ataxia telangiectasia (AT). Clin Exp Immunol 2000;119:140-7.

Zielen S, Buhring I, Strnad N, Reichenbach J, Hofmann D. Immunogenicity and tolerance of a 7-valent pneumococcal conjugate vaccine in nonresponders to the 23-valent pneumococcal vaccine. Infect Immun 2000;68:1435-40.

Siler U, Seiffert M, Puch S, Richards A, Torok-Storb B, Muller CA, Sorokin, Klein G. Characterization and functional analysis of laminin isoforms in human bone marrow. Blood 2000; 96: 4194-4203

1999

Reichenbach J, Schubert R, Schwan C, Muller K, Bohles HJ, Zielen S. Anti-oxidative capacity in patients with ataxia telangiectasia. Clin Exp Immunol 1999;117:535-9.

1

Lanini L, Siler U, Prader S, Reichenbach J. Modern management of phagocyte defects. Ped Allergy Immunol 2017 Mar;28(2):124-134

2

Kaufmann K, Chiriaco M, Siler U, Finocchi A, Reichenbach J, Stein S, Grez M. Gene Therapy for Chronic Granulomatous Disease: Current Status and Future Perspectives. Current Gene Therapy 2014; 14(6) : 447-460

3

Hoernes M, Seger R, Reichenbach J. Modern Management of B cell defects. Ped Allergy Immunol 2011; 22(8):758-69.

4

Grez M, Reichenbach J, Schwäble J, Seger R, Dinauer MC, Thrasher A. Gene Therapy of Chronic Granulomatous Disease: The Engraftment Dilemma. Mol Ther 2010; 19:28-35.

5

Casanova JL, Fieschi C, Bustamante J, Reichenbach J, Remus N, v Bernuth H, Picard C. From idiopathic infectious diseases to novel primary immunodeficiencies. J Allergy Clin Immunol 2005;116:426-30.

6

Lawrence T, Puel A, Reichenbach J, Ku CL, Chapgier A, Renner E, Minard-Colin V, Ouachee M, Casanova JL. Autosomal-dominant primary immunodeficiencies. Curr Opin Hematol 2005;12:22-30.

7

Reichenbach J, Rosenzweig S, Doffinger R, Dupuis S, Holland SM, Casanova JL. Mycobacterial diseases in primary immunodeficiencies. Curr Opin Allergy Clin Immunol 2001;1:503-11.

8

Remus N, Reichenbach J, Picard C, Rietschel C, Wood P, Lammas D, Kumararatne DS, Casanova JL. Impaired interferon gamma-mediated immunity and susceptibility to mycobacterial infection in childhood. Pediatr Res 2001;50:8-13.

9

Ott MG, Seger R, Stein S, Siler U, Hoelzer D, Grez M. Advances in the treatment of chronic granulomatous disease by gene therapy. Curr Gene Ther. 2007, 7: 155-61.

10

Stein S, Siler U, Ott MG, Seger R, Grez M. Gene therapy for chronic granulomatous disease. Curr Opin Mol Ther. 2006; 8: 415-22.

11

Siler U, Herzog A, Spitzer V, Seifert N, Denelavas A, Hunziker PB, Barella L, Hunziker W, Lein M, Goralczyk R, Wertz K. Lycopene effects on rat normal prostate and prostate tumor tissue. J Nutr. 2005; 135: 2050S-2S.

12

Wertz K, Siler U, Goralczyk R. Lycopene: mode of action to promote prostate health. Arch. Biochem. Biophys. 2004; 430: 127-134

1

Bianchi M, Niemiec MJ, Siler U, Urban CF, Reichenbach J. Aspergillus infection in CGD and MPO deficiency (Reply). J Allergy Clin Immunol 2011;128(3):687-688.

2

Holland SM, Reichenbach J. Chronic Granulomatous Disease, Catalase, and Actinomyces (Reply). Clin Infect Dis 2010;50(9):1325-1326.

3

Hakkim A, Hurwitz R, Bianchi M, Brinkmann V, Siler U, Seger RA, Zychlinsky A, Reichenbach J. Protecting against Aspergillus infection in CGD (Reply). Blood 2009 114(16): 3498-3498.

1

Siler U, Reichenbach J, Thrasher A. Gene Therapy for CGD, in: “Chronic Granulomatous Disease: Genetics, Biology and Clinical Management”, Nova Science Publishers, 1. Auflage 2017

2

Reichenbach J. Chronische Granulomatose (CGD) und Leukozytenadhäsionsdefekte, in: „Diagnose, Therapie und Prophylaxe von Infektionen bei primären Immundefekt-erkrankungen“ UNI-Med Science Reihe, 1. Auflage 2015

3

Reichenbach J. Gestörte antimykobakterielle Immunität. Pädiatrische Allergologie und Immunologie, Urban & Fischer, München/Jena, 4. Auflage 2005, 668-76.

4

Zielen S, Reichenbach J. Pneumokokken-Infektionen. DGPI Handbuch, Infektionen bei Kindern und Jugendlichen, Futuramed Verlag München, 4. Auflage 2003, 572-7.

5

Zielen S, Reichenbach J, Schmitt HJ. Pneumokokken. Schutzimpfungen 2003, Infomed Medizinische Verlagsgesellschaft Berlin, 3. Auflage 2003, 177-87.

6

Schubert R, Kappenhagen N, Reichenbach J, Zielen S. T-Zellaktivierung bei Ataxia teleangiectatica. Ataxia Teleangiectatica, Edition Medizinische Genetik, 1999, 1:49-51.

7

Wertz K, Siler U, Barella L & Goralczyk R. (2004) Nutrigenomics in Research on Cancer Prevention, Nutrigenomics uncovers new Modes of Action for Lycopene in Prostate Cancer Prevention. In The Increased Role of Nutrition and Genomics in the Prevention and Management of Desease; ed. Ysbrand Poortman; VSOP, Soestdijk, The Netherlands; Chapter 7, pp. 71-86

8

Goralczyk R. & Siler U. (2003) The role of Lycopene in Human Health. In Phytochemicals in Health and Disease; Bao Y. & Fenwick R. ed. Marcel Decker, Inc.: New York; Chapter 14, pp. 285-309